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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH2
All Species:
43.33
Human Site:
S729
Identified Species:
73.33
UniProt:
Q15910
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15910
NP_004447
746
85363
S729
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Chimpanzee
Pan troglodytes
XP_001166174
754
86395
S737
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Rhesus Macaque
Macaca mulatta
XP_001097572
895
101712
S878
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Dog
Lupus familis
XP_532733
751
85949
S734
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61188
746
85318
S729
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Rat
Rattus norvegicus
NP_001128451
746
85233
S729
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Chicken
Gallus gallus
XP_418879
766
87687
S749
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Frog
Xenopus laevis
Q98SM3
748
85365
S731
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
S743
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
G743
L
F
F
D
Y
R
Y
G
P
T
E
Q
L
K
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
S739
L
T
F
D
Y
S
Y
S
G
E
H
Q
I
A
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P4
895
100374
G864
L
F
Y
D
Y
R
Y
G
P
D
Q
A
P
A
W
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
G824
L
F
Y
D
Y
R
Y
G
P
D
Q
A
P
V
W
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
77.8
98.8
N.A.
98.2
98.2
N.A.
97.9
94.2
93
85
N.A.
48.5
N.A.
23.4
N.A.
Protein Similarity:
100
98.9
80.5
99.1
N.A.
99.1
99.1
N.A.
99.1
96
96.5
91.4
N.A.
62.2
N.A.
41.1
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
60
N.A.
40
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
25.7
N.A.
27.4
N.A.
N.A.
Protein Similarity:
N.A.
44.1
N.A.
43.5
N.A.
N.A.
P-Site Identity:
N.A.
46.6
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
60
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
72
0
86
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
100
0
0
0
0
0
15
72
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% E
% Phe:
0
93
86
0
0
0
0
0
0
0
0
0
0
0
15
% F
% Gly:
0
0
0
0
0
0
0
22
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
79
0
% K
% Leu:
100
0
0
0
0
0
0
0
0
0
0
0
79
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
22
0
0
0
15
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
72
0
15
15
0
0
0
% Q
% Arg:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
79
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% W
% Tyr:
0
0
15
0
100
0
100
0
0
0
0
0
0
0
72
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _